Microdosing Magic Mushrooms helps those with depression and anxiety by targeting the serotonergic 5-HT2A receptors, which in turn promotes the production of Brain-Derived Neurotrophic Factor (BDNF) and increases the transmission of Glutamate. Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that is vital to the maintenance, survival, and growth of neurons in key brain circuits which are involved in emotional and cognitive function. Those with anxiety or major depressive disorder are known to have reductions in BDNF, which is why microdosing psilocybin has been used to treat those with depression as it increases the production of BDNF.
Microdosing psilocybin causes parts of the brain that would normally not communicate together to communicate with one another. These brain connections are made by decreasing the activity in our Default Mode Network (DMN), which is often a very overused part of our brain. The DMN in our brains is responsible for numerous mental activities such as thinking about the past/future and self-reflection. With an over-stimulated DMN, these mental thoughts often lead to thoughts of depression and anxiety. Since microdosing has been proven to slow down the activity of our DMN, it leads to humans naturally thinking in new ways which would otherwise be inaccessible to us. These new thought patterns help remove and forget about depressive and anxious thoughts altogether and allow people to be present in the current moment.